Glossary

Adipocytes

Cells responsible for fat tissue formation.

Allogeneic

Cells or tissue obtained from a donor.

Allograft

A tissue graft from a donor of the same species as the recipient but not genetically identical.

Autologous

Cells or tissues obtained from the same individual.

Chondrocytes

Cells responsible for cartilage formation.

DMSO

Dimethyl Sulfoxide is used as cryoprotectant to help preserve organs, tissue and cell suspensions that are undergoing cryo preservation.

FDA 1271 CFR

An industry guidance document for the regulation of human cells, tissue and cellular and tissue-based products (HCT/Ps).

FDA 351

An HCT/P that does not meet the criteria for 361 and therefore is regulated as a drug, device or biological product.

FDA 361

A list of criteria that allows a human cell and tissue products to be used without going through the investigational new drug protocols.

Homologous Use

The repair, reconstruction, replacement or supplementation of a recipients cells or tissues with a human cell and tissue product (HCT/P) that performs the same basic function or functions in the recipient as in the donor.

Mesenchymal Stem Cells

Multipotent stromal cells that can differentiate into a variety of cell types; Osteoblasts, Chondrocytes, Myocytes, Neuronal cells and Adipocytes.

Minimal Manipulation: Non-Structural

Processing that does not alter the relevant biological characteristics of cells or tissues.

Minimal Manipulation: Structural

Processing that does not alter the original relevant characteristics of the tissue relating to the tissue's utility for reconstruction, repair, or replacement.

Multipotent Cells

Multipotent cells can develop into more than one cell type but are more limited than pluripotent cells.

Myocytes

Cells responsible for muscle tissue formation.

Neuronal Cells

Cells responsible for nerve cell formation.

Osteoblasts

Cells responsible for bone formation.

Pluripotent Cells

Pluripotent cells can give rise to all of the cell types that make up the body; embryonic stem cells are considered pluripotent.

Sulfonamide aka Sulfa

A group of man-made medicines that contain the sulfonamide chemical group. It is not the same as sulfoxide used in DMSO.

Stem Cells

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

Totipotent Cells

Totipotent cells can form all the cell types in a body, plus the extraembryonic, or placental, cells. Embryonic cells within the first couple of cell divisions after fertilization are the only cells that are totipotent.